The genetic relationship between epilepsy and hemiplegic migraine
نویسندگان
چکیده
منابع مشابه
The genetic relationship between epilepsy and hemiplegic migraine
Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A, ATP1A2, SCN1A, and PRRT2). A better understanding of the shared g...
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15 صفحه اولA review of the genetic relation between migraine and epilepsy.
A possible relation between migraine and epilepsy has been a matter of debate for many decades. Clinical, epidemiological and therapeutic similarities may be coincidental and are no proof of a common aetiological background. However, a genetically determined dysfunction of ion channels seems to point to a common underlying mechanism for both paroxysmal disorders. For example, mutations in the t...
متن کاملGenetic heterogeneity of familial hemiplegic migraine.
Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with multiple members suffering from hemiplegic migraine were investigated. In two o...
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ژورنال
عنوان ژورنال: Neuropsychiatric Disease and Treatment
سال: 2017
ISSN: 1178-2021
DOI: 10.2147/ndt.s132451